Sign Out
In patients who are unsuited to receive oral therapy omeprazole sodium may be given on a short-term basis by intravenous infusion, in a usual dose equivalent to 40 mg of the base over a period of 20 to 30 minutes in 100 mL of sodium chloride 0.9% or glucose 5%. It may also be given by slow intravenous injection. Higher intravenous doses have been given to patients with Zollinger-Ellison syndrome.
For parenteral dosage in children the BNFC recommends an intravenous dose of 500 micrograms/kg (to a maximum of 20 mg) once daily in children aged 1 month to 12 years; this may be increased to 2 mg/kg (to a maximum of 40 mg) once daily if needed.
Administration in hepatic impairment: Bioavailability and half-life of omeprazole can increase in patients with hepatic impairment. UK licensed product information recommends that a maximum daily oral dose of 20 mg be used in these patients; a daily intravenous dose of 10 to 20 mg is considered sufficient.
